Estradiol valerate/prasterone enanthate
Estradiol valerate/prasterone enanthate (EV/DHEA-E), sold under the brand name Gynodian Depot, is a medication which is used in hormone therapy for menopausal symptoms and low sex hormone levels in women. It is a combination of estradiol valerate, an estrogen, and prasterone enanthate (DHEA-E), an androgen.
Pharmacology
Estradiol valerate/prasterone enanthate is a combination medication of estradiol valerate, an estrogen, and prasterone enanthate, an androgen. The medication is administered by intramuscular injection.
Estradiol valerate
Estradiol valerate is a synthetic ester of the natural estrogen, estradiol. It is one of several esters of estradiol that are used in hormone therapy. Estradiol valerate is converted in the body to estradiol.
Prasterone enanthate
Prasterone enanthate is a synthetic ester of the natural androgen, dehydroepiandrosterone (DHEA). It is one of several esters of DHEA that are used in hormone therapy. Prasterone enanthate is converted in the body to DHEA.
Clinical use
Estradiol valerate/prasterone enanthate is used in hormone therapy for menopausal symptoms and low sex hormone levels in women. It is administered by intramuscular injection.
Side effects
Possible side effects of estradiol valerate/prasterone enanthate include menstrual irregularities, breast tenderness, nausea, and headache.
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Contributors: Prab R. Tumpati, MD
