Estradiol benzoate/testosterone propionate
Estradiol benzoate/testosterone propionate is a combination medication that contains two active ingredients: estradiol benzoate and testosterone propionate. This combination is used in hormone therapy for various medical conditions.
Components
Estradiol Benzoate
Estradiol benzoate is an estrogen ester, a form of the naturally occurring hormone estradiol. It is used in hormone replacement therapy (HRT) for menopausal symptoms, hypogonadism, and other conditions requiring estrogen supplementation.
Testosterone Propionate
Testosterone propionate is an androgen and anabolic steroid (AAS) ester, a form of the naturally occurring hormone testosterone. It is used in the treatment of male hypogonadism, delayed puberty, and other conditions requiring testosterone supplementation.
Medical Uses
The combination of estradiol benzoate and testosterone propionate is primarily used in hormone replacement therapy (HRT) for menopausal women and in the treatment of hypogonadism in men. It helps in alleviating symptoms such as hot flashes, vaginal atrophy, and osteoporosis in women, and in restoring normal testosterone levels in men.
Mechanism of Action
Estradiol Benzoate
Estradiol benzoate works by binding to and activating the estrogen receptors in various tissues, leading to the modulation of gene expression and the alleviation of menopausal symptoms.
Testosterone Propionate
Testosterone propionate works by binding to and activating the androgen receptors in various tissues, leading to the modulation of gene expression and the development of male secondary sexual characteristics.
Side Effects
Common side effects of estradiol benzoate/testosterone propionate include:
Serious side effects may include:
Contraindications
The use of estradiol benzoate/testosterone propionate is contraindicated in individuals with:
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Contributors: Prab R. Tumpati, MD
