Estradiol 3-saccharinylmethyl ether

Estradiol 3-saccharinylmethyl ether is a synthetic, steroidal estrogen that was studied in the 1970s but was never marketed. It is an estrogen ether – specifically, an ether of estradiol – and is described as a long-acting estrogen. The compound is related to other estrogens like estradiol, estradiol benzoate, and estradiol dipropionate.

Chemistry

Estradiol 3-saccharinylmethyl ether, also known as estradiol 3-(O-carboxymethyl)oxime ether, is a synthetic estrane steroid and a derivative of estradiol. It is more specifically a derivative of estradiol with a saccharinylmethyl ether at the C3 position and an oxime at the C17 position.

Pharmacology

As an estrogen, estradiol 3-saccharinylmethyl ether has the ability to bind to and activate the estrogen receptor (ER). It has been found to have high affinity for the ER and to be a potent and long-acting estrogen.

History

Estradiol 3-saccharinylmethyl ether was first described in the literature in 1971. It was studied in animals and was found to have a prolonged duration of action relative to that of estradiol itself. However, the compound was never marketed.

See also

• List of estrogen esters
• List of synthetic estrogens

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Estradiol_3-saccharinylmethyl_ether

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  Saccharinylmethylestradiol