Estradiol dipropionate
Estradiol dipropionate is a form of estrogen, a group of hormones that play an important role in the female reproductive system. It is a synthetic, steroidal estrogen that is used in hormone therapy.
Chemistry[edit]
Estradiol dipropionate is a synthetic steroid and a derivative of estradiol. It is an estrogen ester; specifically, it is the 3,17-dipropionate ester of estradiol. The compound is formed by the esterification of the 3 and 17 hydroxyl groups of estradiol with propionic acid.
Pharmacology[edit]
Estradiol dipropionate is a prodrug of estradiol, meaning it is metabolized in the body to produce estradiol. It is administered via injection and has a longer duration of action than estradiol itself due to the slow release of estradiol from the dipropionate ester.
Medical uses[edit]
Estradiol dipropionate is used in hormone therapy for menopausal symptoms, hypoestrogenism, androgen-dependent prostate cancer, and to support female reproductive health. It is also used in feminizing hormone therapy for transgender women.
Side effects[edit]
Like all estrogens, estradiol dipropionate can have a range of side effects, including mood changes, weight gain, and increased risk of certain types of cancer. It is important for patients to discuss these risks with their healthcare provider before starting treatment.
See also[edit]
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Estradiol dipropionate[edit]
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Estradiol chemical structure
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Estradiol levels after a single intramuscular injection of 50 μg/kg estradiol dipropionate in pubertal girls
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Vaginal cornification with a single intramuscular injection of different estradiol esters in women
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