Dulcin

From WikiMD's medical encyclopedia


Overview

Dulcin is a synthetic chemical compound that was historically used as an artificial sweetener. It is known for its sweet taste, which is approximately 250 times sweeter than sucrose. Dulcin was first synthesized in 1883 by the Polish chemist Joseph Berlinerbau.

Chemical Structure

Dulcin is chemically known as p-ethoxyphenylurea. Its molecular formula is C9H12N2O2. The compound consists of a phenyl group attached to an ethoxy group and a urea moiety. The presence of the ethoxy group contributes to its sweet taste.

Chemical structure of Dulcin

History

Dulcin was introduced as a sweetening agent in the early 20th century. It gained popularity as a sugar substitute due to its intense sweetness and low caloric content. However, concerns about its safety led to a decline in its use.

Safety and Regulation

In the mid-20th century, studies raised concerns about the potential toxicity of Dulcin. Animal studies suggested that it might have carcinogenic properties, leading to its ban in several countries. The United States Food and Drug Administration (FDA) banned Dulcin in 1950.

Uses

Before its ban, Dulcin was used in various food and beverage products as a sugar substitute. It was particularly popular in dietary products aimed at individuals seeking to reduce caloric intake.

Related Compounds

Dulcin is part of a class of compounds known as artificial sweeteners. Other well-known artificial sweeteners include saccharin, aspartame, and sucralose. These compounds are used to provide sweetness without the calories associated with sugar.

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Contributors: Prab R. Tumpati, MD