Don W. Cleveland

Cleveland Don

Don W. Cleveland is an American cell biologist and neuroscientist known for his research on the molecular mechanisms of neurodegenerative diseases. He is a Distinguished Professor of Medicine, Cellular and Molecular Medicine, and Neurosciences at the University of California, San Diego (UCSD).

Early Life and Education

Cleveland was born in New Orleans, Louisiana. He earned his B.S. in Physics from New Mexico State University and his Ph.D. in Biochemistry from Princeton University.

Research and Contributions

Cleveland's research has significantly advanced the understanding of the molecular and genetic underpinnings of neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS) and Huntington's disease. His work has focused on the role of microtubules and motor proteins in cell division and neuronal function.

Amyotrophic Lateral Sclerosis (ALS)

Cleveland has made pioneering contributions to the understanding of ALS, particularly in identifying the role of mutant superoxide dismutase 1 (SOD1) in the disease. His research has led to the development of potential therapeutic strategies, including gene therapy approaches.

Huntington's Disease

In the field of Huntington's disease, Cleveland's work has elucidated the mechanisms by which mutant huntingtin protein causes neuronal death. His research has also explored the potential of RNA interference (RNAi) as a therapeutic strategy for this condition.

Awards and Honors

Cleveland has received numerous awards for his contributions to science, including the Breakthrough Prize in Life Sciences and the National Academy of Sciences membership. He is also a fellow of the American Academy of Arts and Sciences.

Personal Life

Cleveland resides in San Diego, California, where he continues his research and teaching at UCSD.

See Also

• Neurodegenerative disease
• Cell biology
• Gene therapy
• RNA interference