Docusate

Information about Docusate

Docusate is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation.

Docusate Structure

Liver safety of Docusate

Docusate has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury with jaundice.

Mechanism of action of Docusate

Docusate (dok’ ue sate) is a stool softener and surfactant previously known as dioctyl sodium [or calcium] sulfosuccinate (DSS).

Docusate is commonly used to treat or prevent constipation and to promote bowel regularity in hospitalized, bed-bound or immobilized persons. Docusate salts are thought to act as detergents, reducing surface tension of liquids and fatty substances in the intestine, thereby softening stool consistency. The efficacy of docusate in treatment and prevention of constipation has not been well documented. However, extensive experience with its use has documented its safety and tolerability.

FDA approval information for Docusate

Docusate has been in use in the U.S. since the 1950s and current indications are for treatment and prevention of constipation.

Dosage and administration for Docusate

Docusate is available without prescription in capsules of 50, 100, 240 and 250 mg generically and under various brand names such as Colace, Doxidan, Regulex, Silace and Surfak. A liquid formulation for oral use is also available.

The typical oral dose is 50 to 300 mg daily until bowel movements are normal.

Side effects of Docusate

Common side effects include diarrhea, abdominal cramping, nausea, bitter taste and dizziness.

• Dailymed label info on Docusate
• FDA Docusate