Diffuse proliferative nephritis

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Diffuse proliferative nephritis
Synonyms	Diffuse proliferative glomerulonephritis
Pronounce	N/A
Specialty	N/A
Symptoms	Hematuria, proteinuria, hypertension, edema
Complications	Chronic kidney disease, end-stage renal disease
Onset	Variable
Duration	Chronic
Types	N/A
Causes	Often associated with systemic lupus erythematosus
Risks	Autoimmune disorders, genetic predisposition
Diagnosis	Urinalysis, renal biopsy, serology
Differential diagnosis	Focal segmental glomerulosclerosis, membranous nephropathy
Prevention	N/A
Treatment	Immunosuppressive therapy, corticosteroids, antihypertensive drugs
Medication	N/A
Prognosis	Variable, depends on response to treatment
Frequency	Rare
Deaths	N/A

Diffuse proliferative nephritis is a type of glomerulonephritis that is characterized by significant inflammation and proliferation of the cells within the glomerulus of the kidney. This condition can lead to significant kidney damage and, in severe cases, kidney failure.

Causes

Diffuse proliferative nephritis is often caused by an overactive immune system that mistakenly attacks the kidneys. This can occur as a result of certain diseases, such as systemic lupus erythematosus (SLE), Goodpasture's syndrome, and vasculitis. In some cases, the exact cause of diffuse proliferative nephritis is unknown.

Symptoms

The symptoms of diffuse proliferative nephritis can vary greatly depending on the severity of the condition. Common symptoms include blood in the urine (hematuria), protein in the urine (proteinuria), and high blood pressure (hypertension). Other symptoms may include swelling (edema), particularly in the legs and feet, and fatigue.

Diagnosis

Diagnosis of diffuse proliferative nephritis typically involves a combination of medical history, physical examination, and laboratory tests. These tests may include urinalysis, blood tests, and a kidney biopsy.

Treatment

Treatment for diffuse proliferative nephritis typically involves managing the symptoms and slowing the progression of the disease. This may include medications to control high blood pressure, reduce proteinuria, and suppress the immune system. In severe cases, dialysis or a kidney transplant may be necessary.

Diffuse_proliferative_nephritis gallery

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  Diffuse proliferative lupus nephritis - high magnification
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  Renal corpuscle diagram

See also

• Glomerulonephritis
• Systemic lupus erythematosus
• Goodpasture's syndrome
• Vasculitis
• Kidney biopsy
• Dialysis
• Kidney transplant