Development of the cerebral cortex

Development of the Cerebral Cortex

The cerebral cortex is the outermost layer of the brain, responsible for higher cognitive functions such as thought, language, and consciousness. Its development is a complex process that begins during the early stages of embryogenesis and continues into adulthood. This article will focus on the key stages of cortical development, including neurogenesis, migration, and synaptogenesis.

Neurogenesis

Neurogenesis is the process by which neurons are generated from neural stem cells and progenitor cells. In the developing cerebral cortex, this process begins around the third week of gestation and continues until the fifth month. During this time, the neural stem cells undergo a series of divisions to produce a large number of neurons.

Migration

Once the neurons are generated, they must migrate to their final positions in the cerebral cortex. This process, known as neuronal migration, begins around the sixth week of gestation and continues until the end of the second trimester. The neurons migrate along a scaffold of radial glial cells, moving from the inner layers of the cortex to the outer layers in a process known as radial migration.

Synaptogenesis

Synaptogenesis is the process by which neurons form synapses with each other, allowing them to communicate. In the cerebral cortex, this process begins around the third trimester of gestation and continues into adulthood. During this time, the neurons form a complex network of connections, which are continually refined through a process of synaptic pruning.

Cortical Layering

The cerebral cortex is organized into six distinct layers, each with its own unique set of neurons and connections. This layering is established during the process of neuronal migration, with the neurons in the innermost layer (Layer VI) being the first to migrate, and the neurons in the outermost layer (Layer I) being the last.

Clinical Significance

Abnormalities in the development of the cerebral cortex can lead to a range of neurodevelopmental disorders, including autism, schizophrenia, and intellectual disability. Understanding the processes that underlie cortical development is therefore crucial for developing new treatments for these conditions.

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Development of the cerebral cortex

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  Corticogenesis in a wild-type mouse

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  Development of the cerebral cortex