DU145

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DU145

DU145 (pronounced "D-U-One-Four-Five") is a cell line that is commonly used in scientific research, particularly in the field of oncology. It was originally derived from a human prostate cancer metastasis in the brain.

Etymology

The name "DU145" is an abbreviation of "Duke University 145", indicating the institution where the cell line was first established and the number assigned to it.

Description

DU145 cells are adherent, epithelial-like cells. They are known to be androgen-insensitive, meaning they do not respond to the hormone androgen. This characteristic makes them particularly useful in the study of prostate cancer, as many prostate cancers are androgen-dependent.

Use in Research

DU145 cells are widely used in cancer research, especially in the study of prostate cancer. They are often used in in vitro studies to investigate the effects of various drugs or treatments on prostate cancer cells. They are also used in genetic studies to understand the molecular mechanisms of prostate cancer.

Related Terms

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