Cotrifazid

From WikiMD's medical encyclopedia

Cotrifazid is a pharmacological agent that is a combination of two antibiotics, cotrimoxazole and rifampicin. It is primarily used in the treatment of tuberculosis, a serious infectious disease caused by the bacterium Mycobacterium tuberculosis.

Composition

Cotrifazid is a combination of two antibiotics, cotrimoxazole and rifampicin. Cotrimoxazole is a combination of sulfamethoxazole and trimethoprim, which work together to inhibit the growth of bacteria. Rifampicin is a bactericidal antibiotic that inhibits the synthesis of RNA in bacteria, thereby preventing their replication.

Mechanism of Action

The two components of Cotrifazid work synergistically to inhibit the growth and replication of Mycobacterium tuberculosis. Cotrimoxazole inhibits the synthesis of folic acid, a necessary component for bacterial DNA replication. Rifampicin, on the other hand, inhibits the synthesis of RNA, thereby preventing the bacteria from replicating and spreading.

Indications

Cotrifazid is primarily indicated for the treatment of tuberculosis. It may also be used in the treatment of other bacterial infections that are sensitive to the antibiotics it contains.

Side Effects

Like all medications, Cotrifazid can cause side effects. These may include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause serious side effects such as hepatitis, anemia, and thrombocytopenia.

Precautions

Patients with a history of allergy to any of the components of Cotrifazid should not take this medication. It should also be used with caution in patients with liver disease or kidney disease, as these conditions can affect the metabolism and excretion of the drug.

Interactions

Cotrifazid can interact with other medications, including anticoagulants, antidiabetic drugs, and oral contraceptives. These interactions can alter the effectiveness of the medications or increase the risk of side effects.

See Also

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Contributors: Prab R. Tumpati, MD