Combined immunodeficiencies

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Combined immunodeficiencies
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Increased susceptibility to infection, failure to thrive
Complications	Autoimmune disease, cancer
Onset	Usually in infancy or early childhood
Duration	Lifelong
Types	N/A
Causes	Genetic mutations affecting the immune system
Risks	Family history of immunodeficiency
Diagnosis	Genetic testing, blood tests, immunological assays
Differential diagnosis	Severe combined immunodeficiency, HIV/AIDS, other primary immunodeficiencies
Prevention	N/A
Treatment	Bone marrow transplant, immunoglobulin therapy, antibiotics
Medication	N/A
Prognosis	Varies depending on severity and treatment
Frequency	Rare
Deaths	N/A

Combined Immunodeficiencies (CID) are a group of immune system disorders that are characterized by recurrent and severe infections, often from a very young age. These conditions are caused by defects in the immune system that affect the functioning of both the T cells and B cells.

Overview

Combined immunodeficiencies are a group of disorders that primarily affect the immune system. These disorders are characterized by increased susceptibility to infections, particularly those caused by bacteria, viruses, and fungi. The immune system is composed of various types of cells that work together to defend the body against harmful substances. In people with combined immunodeficiencies, the immune system is not able to function properly, leading to recurrent and severe infections.

Causes

Combined immunodeficiencies are usually caused by genetic mutations that affect the development or function of the immune system. These mutations can be inherited from parents or can occur spontaneously during the development of the immune system.

Symptoms

The symptoms of combined immunodeficiencies can vary widely, but they often include recurrent infections, growth delays, and an increased risk of developing autoimmune disorders or cancers. The severity of the symptoms can also vary, with some people experiencing mild symptoms and others experiencing severe and life-threatening complications.

Diagnosis

The diagnosis of combined immunodeficiencies is usually based on a combination of clinical findings, laboratory tests, and genetic testing. Laboratory tests can help to identify abnormalities in the immune system, while genetic testing can help to identify the specific mutation that is causing the disorder.

Treatment

The treatment of combined immunodeficiencies is usually aimed at managing the symptoms and preventing complications. This can include antibiotics to treat infections, immunoglobulin therapy to boost the immune system, and in some cases, bone marrow transplantation to replace the defective immune system.

See Also

• Primary immunodeficiency
• Severe combined immunodeficiency
• Common variable immunodeficiency

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