Coagulative necrosis
Coagulative Necrosis
Coagulative necrosis (/koʊˈæɡjʊlətɪv nɛˈkroʊsɪs/) is a type of necrosis in which the architecture of dead tissue is preserved for a span of at least some days.
Etymology
The term "coagulative" is derived from the Latin word "coagulare", which means to curdle or congeal. "Necrosis" is derived from the Greek word "nekros", meaning dead body or corpse.
Overview
Coagulative necrosis is typically the result of hypoxia or ischemia, such as that which occurs in response to a myocardial infarction. The lack of oxygen (hypoxia) or blood flow (ischemia) causes cell death (necrosis) in a localized area that is surrounded by viable tissues.
Pathophysiology
In coagulative necrosis, the underlying tissue architecture is preserved for at least several days. Presumably, the injury denatures not only the structural proteins but also the enzymes, thereby blocking the proteolysis of the dead cells; as a result, eosinophilic, anucleate cells may persist for days or weeks. Leukocytes are then attracted to the area of necrosis, where they enzymatically lyse the dead cells. This process of removing necrotic tissue is known as phagocytosis.
Related Terms
- Necrosis: The death of cells or tissues from severe injury or disease, especially in a localized area of the body. Causes of necrosis include inadequate blood supply, bacterial infection, traumatic injury, and cancer.
- Hypoxia: A condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.
- Ischemia: A restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism.
- Myocardial Infarction: Commonly known as a heart attack, it occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
- Phagocytosis: The process by which a cell uses its plasma membrane to engulf a large particle, giving rise to an internal compartment called the phagosome.
External links
- Medical encyclopedia article on Coagulative necrosis
- Wikipedia's article - Coagulative necrosis
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