Clofibrate

Clofibrate (pronounced klo-FI-brate) is a lipid-lowering agent that is used in the treatment of hyperlipoproteinemia (abnormally elevated levels of any or all lipids or lipoproteins in the blood). It belongs to the class of fibrate drugs, which are derivatives of fibric acid.

Etymology

The term "Clofibrate" is derived from the chemical name chlorophenoxy-isobutyric acid, indicating its chemical structure. The "-ate" suffix is commonly used in the naming of esters, indicating its classification as a fibrate drug.

Pharmacology

Clofibrate works by activating the peroxisome proliferator-activated receptor alpha (PPARα), a receptor that is involved in the metabolism of carbohydrates and fats, as well as the regulation of insulin levels. Activation of PPARα reduces the levels of triglycerides and increases the production of high-density lipoprotein (HDL) cholesterol, often referred to as "good cholesterol".

Usage

Clofibrate is used to lower cholesterol and triglyceride levels in the blood, thereby reducing the risk of atherosclerosis (hardening of the arteries) and other cardiovascular diseases. It is typically used when diet and other non-medical treatments (such as exercise and weight control) have not been fully successful at lowering cholesterol and triglycerides.

Side Effects

Common side effects of Clofibrate include stomach upset, diarrhea, nausea, and headache. More serious side effects can include muscle pain, tenderness, or weakness; blurred vision; and yellowing of the skin or eyes (jaundice).

Related Terms

External links

Medical encyclopedia article on Clofibrate
Wikipedia's article - Clofibrate

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