Cholesterolosis of gallbladder

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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W8MD medical weight loss NYC and sleep center NYC

Cholesterolosis of gallbladder
Synonyms	Strawberry gallbladder
Pronounce	N/A
Specialty	N/A
Symptoms	Often asymptomatic, may include abdominal pain, nausea, vomiting
Complications	Cholecystitis, gallstones
Onset	Usually in adults
Duration	Chronic
Types	N/A
Causes	Accumulation of cholesterol esters in the gallbladder wall
Risks	Obesity, hyperlipidemia, diabetes mellitus
Diagnosis	Ultrasound, endoscopic ultrasound, histopathology
Differential diagnosis	Cholelithiasis, adenomyomatosis, gallbladder polyps
Prevention	Healthy diet, weight management
Treatment	Cholecystectomy if symptomatic
Medication	N/A
Prognosis	Good with treatment
Frequency	Common
Deaths	N/A

Cholesterolosis of gallbladder is a pathological condition characterized by the accumulation of cholesterol within the mucosal cells of the gallbladder. This condition is often associated with gallstones, but can occur independently.

Etiology

The exact cause of cholesterolosis of gallbladder is not well understood. However, it is believed to be related to abnormalities in the metabolism of cholesterol in the body. Some studies suggest that it may be associated with high levels of cholesterol in the blood, obesity, and a diet high in fat and cholesterol.

Pathophysiology

In cholesterolosis of gallbladder, cholesterol is deposited in the lamina propria of the gallbladder wall. This leads to the formation of yellowish spots or patches, which are often described as "strawberry gallbladder" due to their appearance. The accumulation of cholesterol does not cause inflammation or damage to the gallbladder tissue, but it can lead to the formation of polyps or gallstones.

Clinical Presentation

Patients with cholesterolosis of gallbladder may be asymptomatic or may present with symptoms similar to those of cholecystitis, such as abdominal pain, nausea, and vomiting. The condition is often discovered incidentally during imaging studies or surgery for other conditions.

Diagnosis

The diagnosis of cholesterolosis of gallbladder is usually made based on the characteristic appearance of the gallbladder on imaging studies, such as ultrasound or computed tomography (CT) scan. The definitive diagnosis is made by histological examination of the gallbladder tissue obtained during surgery.

Treatment

The treatment of cholesterolosis of gallbladder is usually conservative, as the condition is often asymptomatic and does not cause complications. However, in cases where the condition is causing symptoms or complications, cholecystectomy (surgical removal of the gallbladder) may be indicated.

Prognosis

The prognosis of cholesterolosis of gallbladder is generally good, as the condition does not cause significant morbidity or mortality. However, patients with this condition may have an increased risk of developing gallstones.

Gallery

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  Histopathology of cholesterolosis with annotated foam cell

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  Gallbladder cholesterolosis micro

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  Gallbladder cholesterolosis intermediate magnification

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  Gallbladder cholesterolosis intermediate magnification cropped

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