CYP4F12

CYP4F12 is a member of the cytochrome P450 superfamily of enzymes. These enzymes are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The CYP4F12 gene is located on chromosome 19 in humans.

Function

CYP4F12 is involved in the metabolism of various endogenous and exogenous compounds. It is known to hydroxylate arachidonic acid and other fatty acids, playing a role in the metabolism of eicosanoids. Additionally, CYP4F12 has been implicated in the metabolism of certain drugs, including the antihistamine loratadine.

Expression

CYP4F12 is expressed in various tissues, including the liver, kidney, and intestine. Its expression levels can vary significantly between individuals, which can influence the metabolism of drugs and other compounds.

Clinical Significance

Variations in the CYP4F12 gene can affect the enzyme's activity and, consequently, an individual's response to certain medications. Understanding these variations can be important for personalized medicine approaches, where drug treatments are tailored to an individual's genetic makeup.

Related Enzymes

CYP4F12 is part of the larger CYP4F subfamily, which includes other enzymes such as CYP4F2 and CYP4F3. These enzymes share similar functions and are involved in the metabolism of fatty acids and eicosanoids.

See Also

• Cytochrome P450
• Drug metabolism
• Arachidonic acid
• Eicosanoids
• Personalized medicine

External Links

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