CUMYL-PINACA

CUMYL-PINACA
INN
Drug class
Routes of administration
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Bioavailability
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CAS Number	1400742-14-7
PubChem	118796952
DrugBank
ChemSpider	29762284
KEGG

Synthetic cannabinoid

CUMYL-PINACA is a synthetic cannabinoid that has been used as an active ingredient in synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system.

Chemical Structure and Properties

CUMYL-PINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide. The compound has a molecular formula of C₂₂H₂₅N₃O and a molecular weight of 347.46 g/mol.

Pharmacology

CUMYL-PINACA acts as a potent agonist at the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes including pain sensation, appetite, and mood. The activation of these receptors by CUMYL-PINACA can lead to effects similar to those produced by tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Legal Status

CUMYL-PINACA is classified as a Schedule I substance under the Controlled Substances Act in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use. In the United Kingdom, it is classified as a Class B drug under the Misuse of Drugs Act 1971. In Canada, it is listed under Schedule II of the Controlled Drugs and Substances Act.

Health Risks and Toxicity

The use of synthetic cannabinoids like CUMYL-PINACA has been associated with a range of adverse health effects, including tachycardia, hypertension, nausea, vomiting, hallucinations, and seizures. Due to its potency and the variability in the composition of synthetic cannabis products, the risk of overdose and severe toxicity is significant.

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