CREBBP

CREBBP

CREBBP (pronounced as "C-R-E-B-B-P"), also known as CREB-binding protein, is a gene that encodes a protein which acts as a transcriptional coactivator. The full name of this gene is cAMP response element-binding protein (CREB) binding protein.

Etymology

The name CREBBP is an acronym derived from cAMP response element-binding protein (CREB) binding protein. The term cAMP stands for cyclic adenosine monophosphate, a second messenger important in many biological processes, and CREB is a cellular transcription factor which binds to certain DNA sequences called cAMP response elements, thereby increasing or decreasing the transcription of the genes.

Function

The protein encoded by the CREBBP gene functions as a histone acetyltransferase, which regulates transcription via chromatin remodeling. It is important in the processes of cell differentiation and embryogenesis. Mutations in this gene have been associated with Rubinstein-Taybi syndrome, a condition characterized by mental retardation and broad thumbs and toes.

Related Terms

• Transcription
• Gene expression
• Chromatin remodeling
• Histone acetyltransferase
• Rubinstein-Taybi syndrome

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