Cadherin

Cadherin refers to a class of type II transmembrane proteins that play a crucial role in cell adhesion, ensuring that cells within tissues are bound together. These proteins are dependent on calcium ions (Ca2+) to function, which is why they are often referred to as calcium-dependent adhesion molecules. Cadherins are pivotal in the development and maintenance of tissue architecture and cell signaling, influencing processes such as morphogenesis, cell migration, and wound healing.

Structure and Function

Cadherins are characterized by their extracellular domain, which comprises repeated cadherin motifs that facilitate homophilic binding (binding to the same type of cadherin on adjacent cells). This interaction is calcium-dependent, requiring the presence of calcium ions to stabilize the cadherin structure and promote adhesion. The intracellular domain of cadherins interacts with catenins, a group of proteins that link cadherins to the actin cytoskeleton, providing mechanical strength to the cell-cell junctions.

There are several types of cadherins found in the body, including E-cadherin (epithelial), N-cadherin (neural), and P-cadherin (placental), each with a specific tissue distribution and function. E-cadherin, for example, is crucial for the maintenance of epithelial cell layers, while N-cadherin is important in the nervous system.

Role in Disease

Alterations in cadherin expression or function can lead to a variety of diseases. For instance, the loss of E-cadherin expression is a hallmark of epithelial-mesenchymal transition (EMT), a process implicated in cancer progression and metastasis. Similarly, mutations in cadherin genes have been linked to genetic disorders such as hereditary diffuse gastric cancer and arrhythmogenic right ventricular cardiomyopathy.

Research and Therapeutic Implications

Given their central role in cell adhesion and signaling, cadherins are a focus of research for developing therapeutic interventions in cancer and other diseases. Strategies to modulate cadherin function include the use of monoclonal antibodies, peptides, and small molecule inhibitors that can either promote or inhibit cadherin-mediated adhesion.

See Also

• Cell adhesion molecule
• Integrin
• Selectin

References

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  Adherens Junctions structural proteins

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  Protocadherins

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  E-Cadherin repeating unit