Brincidofovir

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Brincidofovir

Brincidofovir (pronounced as brin-si-doh-foh-veer) is an experimental antiviral drug developed by Chimerix for the treatment of various DNA viruses, including cytomegalovirus, adenovirus, and smallpox.

Etymology

The name "Brincidofovir" is derived from the chemical structure of the drug, which is a cidofovir (an antiviral medication) derivative with a lipid conjugate (brincidofovir is a lipid ester of cidofovir).

Usage

Brincidofovir is primarily used in the treatment of infections caused by DNA viruses. It has shown potential in treating cytomegalovirus infections in patients with weakened immune systems, such as those undergoing organ transplants. It is also being studied for its potential use in treating adenovirus and smallpox infections.

Mechanism of Action

Brincidofovir works by inhibiting the replication of viral DNA. It is a prodrug, which means it is metabolized into its active form inside the body. Once activated, it interferes with the viral DNA polymerase, an enzyme that viruses need to replicate their DNA.

Related Terms

  • Antiviral drug: A type of medication used to treat viral infections.
  • Cidofovir: An antiviral medication that is the parent compound of brincidofovir.
  • DNA virus: A type of virus that uses DNA as its genetic material.
  • Cytomegalovirus: A type of herpesvirus that can cause serious disease in people with weakened immune systems.
  • Adenovirus: A type of virus that can cause a range of illnesses, from mild respiratory infections to serious multi-organ disease.
  • Smallpox: A highly contagious and deadly disease caused by the variola virus. It was eradicated worldwide by 1980, but stocks of the virus are kept for research purposes.

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