Brain-specific angiogenesis inhibitor 2

Brain-specific angiogenesis inhibitor 2 (BAI2) is a protein that in humans is encoded by the ADGRB2 gene. It is a member of the adhesion G protein-coupled receptor family, which is characterized by a long N-terminal extracellular domain.

Function

BAI2 is a seven-transmembrane protein with a large extracellular domain. It is thought to be involved in the suppression of angiogenesis, the physiological process through which new blood vessels form from pre-existing vessels. This is achieved through the inhibition of endothelial cell proliferation. BAI2 is expressed in the brain where it may play a role in the maintenance of vascular integrity.

Clinical significance

Alterations in the ADGRB2 gene have been associated with various neurological disorders, including epilepsy and schizophrenia. Further research is needed to fully understand the role of BAI2 in these conditions.

See also

• Adhesion G protein-coupled receptor
• Angiogenesis
• Blood vessel
• Brain
• Epilepsy
• Schizophrenia

External links

• ADGRB2 at the National Center for Biotechnology Information

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