BMI1
BMI1
BMI1 (pronounced: B-M-I-One), also known as BMI1 proto-oncogene, polycomb ring finger, is a protein that in humans is encoded by the BMI1 gene.
Pronunciation
The term is pronounced as "B-M-I-One".
Etymology
The term "BMI1" is an abbreviation for "B lymphoma Mo-MLV insertion region 1 homolog". It is named so because it was first identified as an oncogene in murine leukemia viruses.
Function
BMI1 is a member of the polycomb group (PcG) family. PcG family members are known to form protein complexes that are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The BMI1 protein, in particular, is involved in maintaining the proliferative state of stem cells, including hematopoietic and neural stem cells.
Clinical Significance
Alterations in the BMI1 gene are associated with several types of cancer, including breast cancer, colorectal cancer, and gastric cancer. It is also implicated in the self-renewal of stem cells, and its overexpression has been linked to increased risk of tumor development and progression.
Related Terms
- Polycomb group: A family of proteins that form complexes involved in maintaining the transcriptional repressive state of genes.
- Oncogene: A gene that has the potential to cause cancer.
- Stem cells: Undifferentiated cells capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cell arise by differentiation.
See Also
External links
- Medical encyclopedia article on BMI1
- Wikipedia's article - BMI1
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