Autosplenectomy
Autosplenectomy (pronounced: auto-sple-necto-my) is a medical term referring to the process where the spleen undergoes fibrosis and atrophy, effectively 'removing' itself. This condition is often a complication of diseases such as sickle cell anemia and other hemolytic anemias.
Etymology
The term 'Autosplenectomy' is derived from the Greek words 'auto' meaning self, 'splen' meaning spleen, and 'ectomy' meaning removal.
Process
In Autosplenectomy, the spleen undergoes a process of fibrosis and atrophy due to repeated episodes of infarction and inflammation. This is often seen in conditions where the normal shape or function of the red blood cells is altered, leading to their premature destruction in the spleen. Over time, this leads to scarring and shrinkage of the spleen, effectively resulting in its 'self-removal'.
Related Terms
- Spleen: An organ involved in producing and removing blood cells in most vertebrates and forming part of the immune system.
- Fibrosis: The thickening and scarring of connective tissue, usually as a result of injury.
- Atrophy: Gradual decline in effectiveness or vigor due to underuse or neglect.
- Infarction: Tissue death (necrosis) due to inadequate blood supply to the affected area.
- Inflammation: A localized physical condition in which part of the body becomes reddened, swollen, hot, and often painful, especially as a reaction to injury or infection.
- Hemolytic Anemia: A condition in which red blood cells are destroyed and removed from the bloodstream before their normal lifespan is over.
See Also
External links
- Medical encyclopedia article on Autosplenectomy
- Wikipedia's article - Autosplenectomy
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