Antiandrogens
Antiandrogens
Antiandrogens (pronunciation: an-tee-an-dro-jens), also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from expressing their biological effects in the body. They are commonly used in the treatment of conditions like prostate cancer, hirsutism, and gender dysphoria.
Etymology
The term "antiandrogen" is derived from the prefix "anti-", meaning against, and "androgen", referring to the group of hormones that play a role in male traits and reproductive activity.
Types of Antiandrogens
There are three main types of antiandrogens:
- Steroidal antiandrogens (cyproterone acetate, medroxyprogesterone acetate, megestrol acetate, spironolactone)
- Nonsteroidal antiandrogens (bicalutamide, flutamide, nilutamide, enzalutamide)
- Androgen synthesis inhibitors (abiraterone acetate, ketoconazole, finasteride, dutasteride)
Each type works differently to block the effects of androgens.
Uses
Antiandrogens are used in a variety of medical conditions, including:
- Prostate cancer: Antiandrogens are often used in combination with other treatments to manage prostate cancer.
- Hirsutism: In women, antiandrogens can be used to treat hirsutism, a condition characterized by excessive hair growth.
- Gender dysphoria: Antiandrogens are used as part of hormone therapy for transgender women.
Side Effects
Like all medications, antiandrogens can cause side effects. These may include fatigue, nausea, hot flashes, and sexual dysfunction. It's important to discuss these potential side effects with a healthcare provider before starting treatment.
External links
- Medical encyclopedia article on Antiandrogens
- Wikipedia's article - Antiandrogens
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