AmpliChip CYP450 Test
AmpliChip CYP450 Test
The AmpliChip CYP450 Test (pronounced am-pli-chip sip-four-fifty test) is a diagnostic tool used in the field of pharmacogenomics.
Etymology
The term "AmpliChip" is a brand name, while "CYP450" refers to the cytochrome P450 enzymes that the test is designed to analyze.
Definition
The AmpliChip CYP450 Test is a microarray-based genotyping test that identifies variations in two genes, CYP2D6 and CYP2C19, which are part of the cytochrome P450 system. These genes are responsible for metabolizing a significant number of commonly prescribed drugs, including antidepressants, antipsychotics, beta-blockers, and some chemotherapy drugs.
Usage
The test is used to predict how an individual might respond to certain medications, based on their genetic makeup. This can help healthcare providers to personalize treatment plans, potentially improving efficacy and reducing the risk of adverse drug reactions.
Related Terms
- Pharmacogenomics: The study of how genes affect a person's response to drugs.
- Cytochrome P450: A group of enzymes that play a major role in drug metabolism and elimination.
- Microarray: A high-throughput technology used to analyze gene expression or to genotype multiple regions of a genome.
- Genotyping: The process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence.
- CYP2D6 and CYP2C19: Two important enzymes in the cytochrome P450 system that metabolize many drugs.
External links
- Medical encyclopedia article on AmpliChip CYP450 Test
- Wikipedia's article - AmpliChip CYP450 Test
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