Alternating hemiplegia
Alternating Hemiplegia (pronunciation: al-ter-nat-ing hemi-ple-gia) is a rare neurological disorder that affects one side of the body (hemiplegia) and alternates between the two sides. The term originates from the Greek words hemi meaning half and plegia meaning paralysis.
Definition
Alternating hemiplegia is a condition characterized by recurrent episodes of temporary paralysis, typically affecting one side of the body. The paralysis alternates from one side of the body to the other, hence the term "alternating". The episodes can last from a few minutes to several days.
Symptoms
The symptoms of alternating hemiplegia include paralysis on one side of the body, dystonia (abnormal muscle tone), ataxia (lack of muscle control), and nystagmus (rapid involuntary eye movement). Other symptoms may include epileptic seizures, developmental delay, and intellectual disability.
Causes
Alternating hemiplegia is caused by mutations in the ATP1A3 gene. This gene provides instructions for producing a protein that is involved in pumping ions across cell membranes. The ATP1A3 gene mutations that cause alternating hemiplegia result in a protein that is less effective at pumping ions, which disrupts the normal function of nerve cells.
Diagnosis
The diagnosis of alternating hemiplegia is based on the clinical symptoms and genetic testing to identify mutations in the ATP1A3 gene.
Treatment
There is currently no cure for alternating hemiplegia. Treatment is symptomatic and supportive, and may include medications to manage seizures and dystonia.
See Also
External links
- Medical encyclopedia article on Alternating hemiplegia
- Wikipedia's article - Alternating hemiplegia
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