Alphamethadol

Alphamethadol

Alphamethadol is a synthetic opioid analgesic and a derivative of methadone. It is used primarily in the treatment of severe pain and as a maintenance therapy for opioid dependence. Alphamethadol is known for its long duration of action and is classified as a Schedule I controlled substance in the United States.

Chemical Structure and Properties

Alphamethadol is chemically similar to methadone, with the chemical formula C21H27NO. It is a racemic mixture, meaning it contains two enantiomers, which are mirror images of each other. The drug is typically administered in its hydrochloride salt form.

Pharmacology

Alphamethadol acts on the mu-opioid receptor, producing effects similar to those of other opioids, such as morphine and heroin. It has a high affinity for these receptors, leading to potent analgesic effects. The drug's long half-life allows for less frequent dosing compared to other opioids.

Medical Uses

Alphamethadol is used in the management of chronic pain and in opioid substitution therapy. It helps reduce withdrawal symptoms and cravings in individuals addicted to opioids. Due to its potency and potential for abuse, its use is highly regulated.

Side Effects

Common side effects of alphamethadol include:

• Nausea
• Vomiting
• Constipation
• Drowsiness
• Dizziness

Serious side effects may include respiratory depression, hypotension, and potential for addiction and abuse.

Regulation and Legal Status

In the United States, alphamethadol is classified as a Schedule I controlled substance under the Controlled Substances Act. This classification indicates that it has a high potential for abuse and no accepted medical use in treatment.

History

Alphamethadol was first synthesized in the mid-20th century as part of research into synthetic opioids. It was developed as an alternative to methadone for pain management and opioid dependence treatment.

See Also

• Methadone
• Opioid
• Analgesic
• Opioid dependence
• Controlled Substances Act

Related Pages

• Methadone
• Opioid
• Analgesic
• Opioid dependence
• Controlled Substances Act