Aescin

Aescin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum (horse chestnut). Aescin is the main active compound in horse chestnut, and is responsible for most of its medicinal properties. High levels of aescin are found in the seeds, leaves and bark of the horse chestnut tree.

Uses

Aescin is used in the treatment of chronic venous insufficiency, varicose veins, and hemorrhoids. It is also used to reduce inflammation and swelling after surgery or injury, particularly following sports injuries, surgery on the veins, or broken bones.

Mechanism of Action

Aescin reduces inflammation and swelling by reducing the rate of fluid leakage from veins and capillaries into surrounding tissue. This is achieved by reducing the number and size of the small pores in the walls of the veins and capillaries. Aescin also improves the tone of the veins, making them less susceptible to damage and leakage.

Side Effects

Side effects of aescin can include stomach upset, headache, dizziness, and allergic skin reactions. In rare cases, kidney or liver damage can occur.

Contraindications

Aescin should not be used by people with kidney or liver disease, or by pregnant or breastfeeding women without medical supervision. It should also not be used by people who are allergic to horse chestnut.

Interactions

Aescin may interact with anticoagulant and antiplatelet drugs, increasing the risk of bleeding. It may also interact with other medicines that are broken down by the liver.

Dosage

The typical dosage of aescin for chronic venous insufficiency is 100-150 mg per day, divided into two or three doses. For hemorrhoids, a topical cream or ointment containing 2% aescin can be applied as needed.

References

• MedlinePlus: Horse Chestnut
• WebMD: Horse Chestnut

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