Acuitas Therapeutics
Acuitas Therapeutics
Acuitas Therapeutics is a biotechnology company based in Vancouver, Canada, known for its development of lipid nanoparticle (LNP) delivery systems for mRNA therapeutics. The company has gained prominence for its role in the development of COVID-19 vaccines, particularly in collaboration with BioNTech and Pfizer.
History
Acuitas Therapeutics was founded in 2009 by a team of scientists with expertise in lipid nanoparticle technology. The company was established to advance the development of LNP systems for the delivery of nucleic acid therapeutics, including mRNA, siRNA, and DNA molecules.
Technology
The core technology of Acuitas Therapeutics is its proprietary lipid nanoparticle delivery system. LNPs are tiny particles that can encapsulate nucleic acids, protecting them from degradation and facilitating their delivery into cells. This technology is crucial for the effective delivery of mRNA vaccines, as it ensures that the mRNA is delivered intact to the target cells, where it can be translated into proteins that elicit an immune response.
Collaborations
Acuitas Therapeutics has collaborated with several pharmaceutical companies and research institutions to advance the development of mRNA-based therapeutics. One of the most notable collaborations is with BioNTech and Pfizer for the development of the Pfizer-BioNTech COVID-19 vaccine. Acuitas provided the LNP technology that enabled the delivery of the mRNA encoding the SARS-CoV-2 spike protein, which is the basis of the vaccine.
Impact on COVID-19 Pandemic
The collaboration between Acuitas Therapeutics, BioNTech, and Pfizer has been instrumental in the rapid development and deployment of the Pfizer-BioNTech COVID-19 vaccine. The success of this vaccine has demonstrated the potential of mRNA technology and LNP delivery systems in addressing global health challenges.
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Contributors: Prab R. Tumpati, MD
