ARID3A

ARID3A is a protein that in humans is encoded by the ARID3A gene. This protein is also known as AT-rich interactive domain-containing protein 3A. It is a member of the ARID (AT-rich interaction domain) family of proteins, which have diverse functions but are all involved in DNA-binding.

Function

The ARID3A protein is a transcription factor that binds to AT-rich sequences in the promoter regions of various genes. It is involved in the regulation of cell differentiation and cell cycle progression, and it plays a crucial role in the development of the immune system and the nervous system. Mutations in the ARID3A gene can lead to various diseases, including cancer and autoimmune diseases.

Structure

The ARID3A protein consists of 228 amino acids and has a molecular weight of approximately 25 kDa. It contains an ARID domain, which is responsible for DNA-binding, and a transactivation domain, which is involved in the regulation of gene expression.

Clinical significance

Alterations in the ARID3A gene have been associated with various types of cancer, including breast cancer, ovarian cancer, and gastric cancer. In these cancers, ARID3A is often overexpressed, leading to increased cell proliferation and decreased cell differentiation. In addition, mutations in the ARID3A gene have been linked to autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

Research

Research on ARID3A is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target. For example, drugs that inhibit the activity of ARID3A could potentially be used to treat cancers in which this protein is overexpressed.

The structure of the ARID3A protein.

See also

• ARID domain
• Transcription factor
• DNA-binding protein

References

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