5F-CUMYL-PINACA
Synthetic cannabinoid
5F-CUMYL-PINACA is a synthetic cannabinoid that has been used as an active ingredient in synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system.
Chemical Structure
5F-CUMYL-PINACA belongs to the indazole family of synthetic cannabinoids. Its chemical structure includes a 5-fluoropentyl chain, an indazole core, and a carboxamide group. The IUPAC name for 5F-CUMYL-PINACA is 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide.
Pharmacology
5F-CUMYL-PINACA acts as a potent agonist at the CB1 receptor and CB2 receptor, which are G-protein coupled receptors in the endocannabinoid system. These receptors are involved in various physiological processes including pain sensation, mood, and memory. The activation of these receptors by 5F-CUMYL-PINACA can lead to psychoactive effects similar to those produced by tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Legal Status
The legal status of 5F-CUMYL-PINACA varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. For example, in the United States, it may be considered an analogue of a Schedule I substance under the Federal Analogue Act.
Health Risks
The use of 5F-CUMYL-PINACA has been associated with various adverse health effects. These can include tachycardia, hypertension, nausea, vomiting, anxiety, and hallucinations. In severe cases, it can lead to seizures, acute kidney injury, and even death.
Detection in Biological Fluids
5F-CUMYL-PINACA and its metabolites can be detected in biological fluids such as urine and blood using various analytical techniques, including liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS).
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