4'-Methyl-α-pyrrolidinopropiophenone
Synthetic stimulant drug
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4'-Methyl-α-pyrrolidinopropiophenone (also known as 4-MePPP) is a synthetic stimulant drug of the cathinone class. It is chemically related to α-pyrrolidinopropiophenone (α-PPP) and is known for its psychoactive effects.
Chemical Structure and Properties
4'-Methyl-α-pyrrolidinopropiophenone is a derivative of α-PPP, with a methyl group added to the para position of the phenyl ring. Its chemical formula is C14H19NO, and it has a molar mass of 217.31 g/mol. The compound features a pyrrolidine ring, which is a common structural motif in many synthetic stimulants.
Pharmacology
4-MePPP acts as a central nervous system stimulant. It is believed to exert its effects by increasing the levels of neurotransmitters such as dopamine and norepinephrine in the brain, similar to other stimulants in the cathinone class. This increase in neurotransmitter levels leads to enhanced alertness, energy, and euphoria.
Effects and Usage
The effects of 4-MePPP are similar to those of other synthetic stimulants, including increased heart rate, elevated blood pressure, and heightened alertness. Users may also experience euphoria, increased sociability, and decreased appetite. However, the use of 4-MePPP can also lead to adverse effects such as anxiety, paranoia, and cardiovascular issues.
Legal Status
The legal status of 4-MePPP varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it may be unregulated, although this is subject to change as new legislation is enacted.
Safety and Toxicity
The safety profile of 4-MePPP is not well-established, and its use is associated with potential health risks. As with other synthetic stimulants, there is a risk of overdose, which can lead to severe cardiovascular and neurological complications. Long-term use may also result in dependence and withdrawal symptoms.
Related Compounds
4-MePPP is part of a broader class of synthetic stimulants known as substituted cathinones. Other related compounds include mephedrone, methylone, and MDPV. These substances share similar chemical structures and pharmacological effects.
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Contributors: Prab R. Tumpati, MD