3-Methyl-GABA

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3-Methyl-GABA

Chemical structure of 3-Methyl-GABA

3-Methyl-GABA (3-methyl gamma-aminobutyric acid) is a chemical compound that belongs to the class of gamma-aminobutyric acid (GABA) analogs. It is a derivative of the neurotransmitter GABA, which is the primary inhibitory neurotransmitter in the central nervous system of mammals.

Chemical Structure

3-Methyl-GABA is characterized by the addition of a methyl group at the third carbon of the GABA molecule. This modification alters its pharmacological properties compared to the parent compound, GABA. The chemical structure of 3-Methyl-GABA is depicted in the adjacent image.

Pharmacology

As a GABA analog, 3-Methyl-GABA interacts with the GABA receptors in the brain. However, the presence of the methyl group can affect its binding affinity and efficacy at these receptors. The exact pharmacological effects of 3-Methyl-GABA can vary depending on its interaction with different subtypes of GABA receptors.

Potential Applications

Research into GABA analogs like 3-Methyl-GABA is ongoing, with potential applications in the treatment of neurological disorders such as epilepsy, anxiety disorders, and chronic pain. The modification of GABA molecules aims to enhance their therapeutic effects while minimizing side effects.

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Contributors: Prab R. Tumpati, MD