13-Fluorolysergol

Chemical compound

Chemical structure of 13-Fluorolysergol

13-Fluorolysergol is a chemical compound that belongs to the class of ergoline derivatives. It is a fluorinated analog of lysergol, which is a naturally occurring ergoline alkaloid. The modification involves the substitution of a fluorine atom at the 13th position of the lysergol molecule.

Chemical Structure and Properties

13-Fluorolysergol is characterized by the presence of a fluorine atom at the 13th position of the ergoline skeleton. This modification can significantly alter the pharmacological properties of the compound compared to its non-fluorinated counterpart, lysergol. The presence of the fluorine atom can affect the compound's lipophilicity, metabolic stability, and receptor binding affinity.

Synthesis

The synthesis of 13-Fluorolysergol involves the introduction of a fluorine atom into the lysergol structure. This can be achieved through various synthetic routes, often involving the use of fluorinating agents. The synthesis process requires careful control of reaction conditions to ensure the selective fluorination at the desired position without affecting other functional groups in the molecule.

Pharmacology

As an ergoline derivative, 13-Fluorolysergol is expected to interact with various serotonin receptors, similar to other compounds in this class. The fluorine substitution may enhance or modify its activity at these receptors, potentially leading to differences in its pharmacological profile. However, detailed studies on its receptor binding and activity are necessary to fully understand its pharmacological effects.

Potential Applications

The unique properties of 13-Fluorolysergol, due to its fluorine substitution, may make it a candidate for research in various fields, including neuropharmacology and medicinal chemistry. Its potential applications could include the development of new therapeutic agents targeting serotonin receptors or as a tool in receptor mapping studies.

Safety and Toxicology

As with many ergoline derivatives, the safety and toxicological profile of 13-Fluorolysergol would need to be thoroughly evaluated. The introduction of a fluorine atom can alter the compound's toxicity and metabolism, necessitating comprehensive studies to assess its safety for any potential therapeutic use.

Related Pages

• Lysergol
• Ergoline
• Serotonin receptor
• Fluorine