Immunodeficiency 26

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Immunodeficiency 26
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Recurrent infections, autoimmune disorders
Complications	Increased risk of cancer
Onset	Childhood
Duration	Lifelong
Types	N/A
Causes	Genetic mutations in the SP110 gene
Risks	Family history of the condition
Diagnosis	Genetic testing, blood tests
Differential diagnosis	Other forms of immunodeficiency
Prevention	N/A
Treatment	Immunoglobulin therapy, antibiotics, hematopoietic stem cell transplantation
Medication	N/A
Prognosis	Variable, depending on severity and treatment
Frequency	Rare
Deaths	N/A

Immunodeficiency is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Immunodeficiencies can be classified as either primary or secondary.

Types of Immunodeficiency

Primary Immunodeficiency

Primary immunodeficiencies are usually genetic and present at birth. They are often inherited in an autosomal recessive pattern, as depicted in the diagram. These conditions are rare and can affect various components of the immune system, including B cells, T cells, and complement proteins.

Secondary Immunodeficiency

Secondary immunodeficiencies are acquired later in life and are more common than primary immunodeficiencies. Causes include HIV/AIDS, malnutrition, and certain medical treatments such as chemotherapy and immunosuppressive drugs.

Symptoms

Individuals with immunodeficiency may experience frequent and severe infections, which can be recurrent and difficult to treat. Common symptoms include:

• Recurrent pneumonia
• Chronic sinusitis
• Persistent diarrhea
• Skin infections

Diagnosis

Diagnosis of immunodeficiency involves a combination of clinical evaluation and laboratory tests. These may include:

• Complete blood count (CBC)
• Quantitative immunoglobulins
• Specific antibody response tests
• Genetic testing for primary immunodeficiencies

Treatment

Treatment depends on the type and severity of the immunodeficiency. Options may include:

• Antibiotics to treat infections
• Immunoglobulin therapy
• Bone marrow transplant for severe cases
• Lifestyle modifications to reduce infection risk

See also

• Immune system
• Autoimmune disease
• HIV/AIDS
• Vaccination