Clocortolone pivalate

A topical corticosteroid used in dermatology

Clocortolone pivalate
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Clocortolone pivalate is a topical corticosteroid used in dermatology for the treatment of various skin conditions. It is known for its anti-inflammatory, antipruritic, and vasoconstrictive properties.

Pharmacology

Clocortolone pivalate is a medium-potency corticosteroid. It works by inhibiting the release of substances in the body that cause inflammation. The mechanism of action involves the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.

Clinical uses

Clocortolone pivalate is primarily used to treat inflammatory skin conditions such as eczema, psoriasis, and dermatitis. It is applied topically to the affected area, usually in the form of a cream. The medication is typically used for short-term treatment to avoid potential side effects associated with long-term corticosteroid use.

Side effects

Common side effects of clocortolone pivalate include skin irritation, dryness, and itching at the site of application. Prolonged use can lead to more serious side effects such as skin thinning, striae, and telangiectasia. Systemic absorption can occur, especially when applied to large areas or under occlusion, potentially leading to adrenal suppression.

Contraindications

Clocortolone pivalate should not be used in individuals with known hypersensitivity to corticosteroids or any component of the formulation. It is also contraindicated in patients with untreated bacterial, viral, or fungal skin infections.

Administration

The cream is typically applied to the affected area two to three times daily. It is important to use the medication as directed by a healthcare provider and to avoid using it on the face, groin, or underarms unless directed by a physician.

Related pages

• Corticosteroid
• Dermatology
• Eczema
• Psoriasis
• Dermatitis