Dexoxadrol

Dexoxadrol

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Chemical structure of Dexoxadrol

Dexoxadrol is a dissociative anesthetic that was developed in the 1970s. It is chemically related to phencyclidine (PCP) and ketamine, and it acts primarily as an NMDA receptor antagonist.

Pharmacology

Dexoxadrol functions by blocking the NMDA receptor, which is a subtype of glutamate receptor. This action inhibits the excitatory neurotransmitter glutamate from binding to the receptor, leading to a decrease in neuronal activity. The result is a dissociative state, characterized by analgesia, amnesia, and catalepsy.

Clinical Use

Although dexoxadrol was initially investigated for its potential use as an anesthetic, it was never marketed for clinical use. The side effects and potential for abuse limited its development. However, its study has contributed to the understanding of NMDA receptor antagonists and their effects on the central nervous system.

Side Effects

The side effects of dexoxadrol are similar to those of other dissociative anesthetics. They include:

• Hallucinations
• Dizziness
• Nausea
• Confusion
• Ataxia

Research

Research into dexoxadrol and related compounds has provided insights into the mechanisms of dissociative anesthesia and the role of NMDA receptors in neurotransmission. Studies have explored its potential effects on neuroplasticity and neuroprotection, although these areas remain largely experimental.

Related Compounds

Dexoxadrol is part of a class of compounds known as arylcyclohexylamines. Other compounds in this class include:

• Phencyclidine (PCP)
• Ketamine
• Dextromethorphan

Related Pages

• NMDA receptor antagonist
• Dissociative drug
• Anesthetic
• Phencyclidine
• Ketamine