A-349821
A selective cannabinoid receptor antagonist
| A-349821 | |
|---|---|
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| CAS Number | 221636-80-6 |
| PubChem | 9829140 |
| DrugBank | |
| ChemSpider | 8004827 |
| KEGG | |
A-349821 is a chemical compound that acts as a selective antagonist for the cannabinoid receptor CB1. It is used primarily in scientific research to study the role of the CB1 receptor in various physiological processes.
Mechanism of Action
A-349821 functions by binding to the CB1 receptor, which is a type of G protein-coupled receptor found predominantly in the central nervous system. By blocking the action of endogenous cannabinoids such as anandamide and 2-arachidonoylglycerol, A-349821 inhibits the downstream signaling pathways that are typically activated by these ligands.
Pharmacological Effects
The blockade of CB1 receptors by A-349821 has been shown to affect several physiological and behavioral processes. These include:
- Modulation of appetite and food intake
- Alteration of pain perception
- Influence on memory and cognition
- Impact on mood and anxiety
Research Applications
A-349821 is primarily used in preclinical research to explore the role of the CB1 receptor in various disease models. It has been instrumental in advancing our understanding of the endocannabinoid system and its potential as a target for therapeutic intervention in conditions such as obesity, chronic pain, and neurodegenerative diseases.
Chemical Properties
A-349821 is characterized by its chemical structure, which includes a dichlorophenyl group, a morpholine ring, and a pyrazole carboxamide moiety. These structural features contribute to its high affinity and selectivity for the CB1 receptor.
Safety and Toxicology
As with many research chemicals, the safety profile of A-349821 is not fully established. It is used under controlled conditions in laboratory settings, and its effects in humans are not well-documented.
Related pages
Gallery
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Chemical structure of A-349821
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