Acetomepregenol

A synthetic progestin

Acetomepregenol
INN
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Routes of administration
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CAS Number	1247-42-3
PubChem	200550
DrugBank
ChemSpider	173611
KEGG	D02899

Acetomepregenol is a synthetic progestin, a type of hormone used in hormonal contraception and hormone replacement therapy. It is a derivative of progesterone, a natural hormone involved in the menstrual cycle and pregnancy.

Chemical structure and properties

Acetomepregenol is a steroid with the chemical formula C₂₂H₃₀O₃. It is characterized by its [[cyclopenta[a]phenanthrene]] structure, which is common to all steroids. The compound includes an acetoxy group at the 17th carbon position, which is a modification that enhances its bioavailability and pharmacokinetics.

Mechanism of action

As a progestin, acetomepregenol mimics the action of progesterone by binding to progesterone receptors in the body. This binding leads to changes in the endometrium that prevent ovulation and alter the cervical mucus, making it more difficult for sperm to enter the uterus.

Uses

Acetomepregenol is primarily used in contraceptive formulations and in hormone replacement therapy for menopausal symptoms. It helps regulate the menstrual cycle and can be used to treat endometriosis and other gynecological disorders.

Side effects

Common side effects of acetomepregenol include nausea, headache, breast tenderness, and mood changes. Long-term use may be associated with an increased risk of thromboembolic events and breast cancer.

Pharmacokinetics

Acetomepregenol is administered orally and is well absorbed in the gastrointestinal tract. It undergoes extensive first-pass metabolism in the liver, and its metabolites are excreted in the urine.

Related pages

• Progestin
• Hormonal contraception
• Hormone replacement therapy
• Progesterone

Gallery

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  Chemical structure of acetomepregenol