25H-NBOMe

A synthetic psychedelic compound

25H-NBOMe
INN
Drug class
Routes of administration	Intranasal, sublingual, buccal
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status	Uncontrolled
CAS Number	1043868-97-8
PubChem	44719680
DrugBank
ChemSpider	21106326
KEGG

25H-NBOMe is a synthetic psychedelic compound that belongs to the NBOMe series. It is a derivative of the phenethylamine 2C-H and is known for its potent hallucinogenic effects.

Chemical structure and properties

25H-NBOMe is chemically classified as a phenethylamine and a substituted amphetamine. Its structure consists of a phenethylamine core with a methoxybenzyl group attached to the nitrogen atom. The presence of the 4-bromo-2,5-dimethoxyphenyl group is characteristic of the NBOMe series, contributing to its high affinity for the serotonin receptors.

Pharmacology

25H-NBOMe acts primarily as a potent agonist of the 5-HT2A receptor, which is responsible for its psychedelic effects. The compound's interaction with this receptor is similar to that of other hallucinogens such as LSD and psilocybin. The binding affinity of 25H-NBOMe to the 5-HT2A receptor is significantly higher than that of its parent compound, 2C-H, due to the presence of the N-benzyl substitution.

Effects

The effects of 25H-NBOMe are similar to those of other psychedelics, including altered perception of time and space, visual hallucinations, and changes in thought processes. The onset of effects typically occurs within 30 to 90 minutes after administration, with the duration lasting up to 12 hours. Due to its potency, 25H-NBOMe is often active at microgram doses.

Safety and toxicity

The safety profile of 25H-NBOMe is not well-established, and its use has been associated with several adverse effects, including vasoconstriction, tachycardia, and hypertension. There have been reports of severe toxicity and fatalities associated with its use, often due to overdose or misidentification as other substances.

Legal status

The legal status of 25H-NBOMe varies by country. In some jurisdictions, it is classified as a controlled substance, while in others, it remains unregulated. The compound is often sold online as a "research chemical," which can complicate legal enforcement.

Related pages

• NBOMe series
• 2C-H
• 5-HT2A receptor
• Psychedelic drug