4-Methoxyestriol

A methoxylated derivative of estriol

4-Methoxyestriol is a methoxylated derivative of the estrogen estriol. It is a naturally occurring estrogenic compound that is part of the estrogen family of hormones.

Structure and Properties

4-Methoxyestriol is a steroidal estrogen with the chemical structure characterized by the presence of a methoxy group at the 4-position of the estriol molecule. This modification distinguishes it from estriol, which lacks the methoxy group.

The molecular formula of 4-Methoxyestriol is C₁₉H₂₆O₄, and it has a molecular weight of 318.41 g/mol. The presence of the methoxy group influences its pharmacokinetics and pharmacodynamics compared to other estrogens.

Biological Activity

4-Methoxyestriol exhibits estrogenic activity, meaning it can bind to and activate estrogen receptors in the body. This activity is similar to other estrogens, but the presence of the methoxy group may alter its binding affinity and potency.

Synthesis and Metabolism

4-Methoxyestriol can be synthesized from estriol through a chemical reaction that introduces the methoxy group at the 4-position. In the body, it may be formed as a metabolite of estriol or other estrogens through enzymatic processes.

Clinical Significance

The clinical significance of 4-Methoxyestriol is not as well-studied as other estrogens like estradiol or estrone. However, its presence and activity in the body suggest it may play a role in estrogen-related physiological processes.

Related Compounds

• Estriol
• Estradiol
• Estrone
• Methoxyestradiol

Related Pages

• Estrogen
• Steroid hormone
• Hormone
• Endocrinology

Gallery

• 
  Chemical structure of 4-Methoxyestriol