4'-Fluorocannabidiol

Synthetic cannabinoid

4'-Fluorocannabidiol (also known as HUF-101) is a synthetic cannabinoid that is structurally related to cannabidiol (CBD). It is characterized by the substitution of a fluorine atom at the 4' position of the phenyl ring of cannabidiol. This modification results in distinct pharmacological properties compared to its non-fluorinated counterpart.

Chemical structure and properties

4'-Fluorocannabidiol is a fluorinated derivative of cannabidiol. The presence of the fluorine atom in the 4' position of the phenyl ring alters the compound's lipophilicity, metabolic stability, and binding affinity to cannabinoid receptors. The chemical formula of 4'-Fluorocannabidiol is C₂₁H₂₉FO₂.

Pharmacology

4'-Fluorocannabidiol interacts with the endocannabinoid system, although its exact mechanism of action and receptor binding profile may differ from that of cannabidiol. The fluorination may enhance its ability to cross the blood-brain barrier and affect its bioavailability.

Potential therapeutic uses

Research into 4'-Fluorocannabidiol is ongoing, with studies exploring its potential therapeutic applications. Like cannabidiol, it may have anti-inflammatory, analgesic, and anxiolytic properties, but the fluorination could modify these effects.

Synthesis

The synthesis of 4'-Fluorocannabidiol involves the introduction of a fluorine atom into the cannabidiol structure. This can be achieved through various chemical reactions, including nucleophilic substitution or electrophilic fluorination.

Legal status

The legal status of 4'-Fluorocannabidiol varies by jurisdiction. As a synthetic cannabinoid, it may be subject to different regulations compared to naturally occurring cannabinoids like cannabidiol.

Related pages

• Cannabidiol
• Synthetic cannabinoids
• Endocannabinoid system

Gallery

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  Chemical structure of 4'-Fluorocannabidiol