3-HO-PCP

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A dissociative anesthetic drug


3-HO-PCP
INN
Drug class
Routes of administration Oral, Intranasal, Intravenous
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status Uncontrolled
CAS Number 79778-41-9
PubChem 44349643
DrugBank
ChemSpider 23274898
KEGG


3-HO-PCP (3-Hydroxyphencyclidine) is a dissociative anesthetic drug that is chemically related to phencyclidine (PCP). It is known for its potent NMDA receptor antagonist properties, which contribute to its dissociative effects.

Pharmacology

3-HO-PCP acts primarily as an NMDA receptor antagonist, which means it inhibits the action of the NMDA receptor, a subtype of glutamate receptor. This inhibition leads to a decrease in the excitatory neurotransmission in the brain, resulting in the characteristic dissociative effects.

The drug also exhibits activity at the sigma receptors, which may contribute to its psychoactive effects. The precise mechanism of action at these receptors is not fully understood.

Effects

The effects of 3-HO-PCP are similar to those of other dissociative anesthetics such as ketamine and PCP. Users may experience:

  • Dissociation
  • Euphoria
  • Hallucinations
  • Altered perception of time and space
  • Analgesia

At higher doses, 3-HO-PCP can cause more severe effects such as:

  • Motor impairment
  • Confusion
  • Agitation
  • Psychosis

Legal Status

As of the current date, 3-HO-PCP is not specifically controlled under international drug control treaties. However, its legal status may vary by country, and it may be subject to analogue laws in jurisdictions where PCP or similar substances are controlled.

Related Compounds

3-HO-PCP is part of a class of compounds known as arylcyclohexylamines, which includes other dissociative anesthetics such as:

See also

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