3F-NEB

Synthetic cannabinoid

3F-NEB
INN
Drug class
Routes of administration	Inhalation, oral
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status	Legal status varies by jurisdiction
CAS Number	1800101-60-3
PubChem	11902592
DrugBank
ChemSpider	10028509
KEGG

3F-NEB is a synthetic cannabinoid that has been used in scientific research and is often found in designer drugs. It is a potent agonist of the cannabinoid receptors, which are part of the endocannabinoid system in the human body.

Chemical Structure and Properties

3F-NEB is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is (1-(5-fluoropentyl)-1H-indazole-3-carbonyl)-L-valine methyl ester. The compound features a fluorinated pentyl chain, which is a common modification in synthetic cannabinoids to enhance their potency and metabolic stability.

The molecular formula of 3F-NEB is C₂₀H₂₇FN₃O₃, and it has a molecular weight of approximately 377.45 g/mol. The presence of the fluorine atom in the pentyl chain is believed to contribute to its high affinity for cannabinoid receptors.

Pharmacology

3F-NEB acts as a full agonist at the CB₁ and CB₂ receptors, which are part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including mood, appetite, and pain sensation.

The activation of these receptors by 3F-NEB can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, synthetic cannabinoids like 3F-NEB can be significantly more potent than THC, leading to increased risks of adverse effects.

Legal Status

The legal status of 3F-NEB varies by jurisdiction. In many countries, synthetic cannabinoids are controlled substances due to their potential for abuse and lack of medical use. It is important for researchers and users to be aware of the legal implications of possessing or distributing 3F-NEB in their respective regions.

Health Risks and Safety

The use of synthetic cannabinoids, including 3F-NEB, has been associated with a range of adverse health effects. These can include tachycardia, hypertension, nausea, vomiting, anxiety, hallucinations, and seizures. In severe cases, use can lead to acute kidney injury and cardiovascular complications.

Due to the variability in potency and the presence of unknown impurities in street formulations, the use of synthetic cannabinoids poses significant health risks. Users should exercise caution and seek medical attention if adverse effects occur.

Related Pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Designer drug
• Endocannabinoid system

Gallery

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  Chemical structure of 3F-NEB