2,5-Dimethoxy-4-trifluoromethylamphetamine

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2,5-Dimethoxy-4-trifluoromethylamphetamine.svg

Psychedelic drug of the amphetamine class


2,5-Dimethoxy-4-trifluoromethylamphetamine (also known as DOTFM) is a psychedelic drug of the substituted amphetamines class. It is a derivative of 4-methyl-2,5-dimethoxyamphetamine (DOM) and is structurally related to other compounds in the 2C family and the DOx family.

Chemical structure and properties[edit]

DOTFM is chemically classified as a phenethylamine and an amphetamine. Its chemical structure consists of a benzene ring with two methoxy groups (–OCH₃) at the 2 and 5 positions, a trifluoromethyl group (–CF₃) at the 4 position, and an ethylamine chain attached to the benzene ring. The presence of the trifluoromethyl group distinguishes DOTFM from other similar compounds.

Pharmacology[edit]

DOTFM acts primarily as a serotonin receptor agonist, particularly at the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects. The exact mechanism of action and the full spectrum of its pharmacological effects are not well understood due to limited research.

Effects[edit]

The effects of DOTFM are similar to those of other psychedelic amphetamines, such as DOM and DOB. Users report experiencing altered perceptions, visual distortions, and changes in thought processes. The duration of effects can vary but typically lasts several hours.

Legal status[edit]

The legal status of DOTFM varies by country. In some jurisdictions, it may be classified as a controlled substance, while in others, it may not be specifically regulated. Users should be aware of the legal implications of possessing or using DOTFM in their respective regions.

History and research[edit]

DOTFM was first synthesized by the American chemist Alexander Shulgin and described in his book PiHKAL (Phenethylamines I Have Known And Loved). Shulgin's work has been instrumental in the study of psychedelic compounds, and DOTFM is one of many substances he explored.

See also[edit]

References[edit]

External links[edit]

Drugs described in PiHKAL



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