Substituted phenylmorpholine

Substituted phenylmorpholine (also known as phenmetrazine analogues) are a chemical class of psychoactive compounds that are based on the phenmetrazine structure. The phenmetrazine structure consists of a phenyl ring bound to a morpholine ring at the R2 position.

History

Phenmetrazine was originally synthesized in the 1950s and was used as an appetite suppressant in the treatment of obesity. However, due to its potential for misuse and addiction, it was withdrawn from the market. This led to the development of various substituted phenylmorpholines, which are designed to mimic the effects of phenmetrazine while reducing its potential for abuse.

Structure and Activity

The structure of substituted phenylmorpholines consists of a phenyl ring bound to a morpholine ring. The morpholine ring is a six-membered ring with one oxygen atom and one nitrogen atom. The phenyl ring is a six-membered carbon ring with five hydrogen atoms and one phenyl group. The position and type of substitution on the phenyl ring can greatly influence the activity of the compound.

Pharmacology

Substituted phenylmorpholines act as stimulants by increasing the levels of certain chemicals in the brain. They are thought to work by inhibiting the reuptake of dopamine, norepinephrine, and serotonin, thereby increasing the levels of these neurotransmitters in the brain. This results in increased alertness, energy, and mood elevation.

Examples

Some examples of substituted phenylmorpholines include:

• 3-Fluorophenmetrazine (3-FPM) - A stimulant drug that is a derivative of phenmetrazine.
• 4-Methylphenmetrazine (4-MPM) - A stimulant drug that is a derivative of phenmetrazine.
• Desoxypipradrol (2-DPMP) - A potent psychostimulant that is structurally related to phenmetrazine.

Legal Status

The legal status of substituted phenylmorpholines varies by country. In some countries, they are classified as controlled substances, while in others they are legal to possess and use.

See Also

• Phenethylamine
• Amphetamine
• Methamphetamine

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