RBM15

RBM15 (RNA Binding Motif Protein 15) is a protein that in humans is encoded by the RBM15 gene. It is a member of the Splicing factor family of proteins, which play a crucial role in RNA splicing, a key process in gene expression.

Function

RBM15 is involved in the regulation of alternative splicing and influences the splice site selection by binding to specific RNA sequences. It also plays a role in the process of X-chromosome inactivation in female mammals, which is a crucial aspect of Sexual differentiation.

Clinical significance

Mutations in the RBM15 gene have been associated with various diseases. For instance, a specific translocation involving the RBM15 gene is associated with Acute megakaryoblastic leukemia, a subtype of Acute myeloid leukemia.

Interactions

RBM15 has been shown to interact with various other proteins, such as OTT1, SAP18, and SIN3A, which are involved in the regulation of gene expression and RNA splicing.

See also

• RNA-binding protein
• Splicing factor
• Gene expression
• Alternative splicing
• X-chromosome inactivation
• Sexual differentiation
• Acute megakaryoblastic leukemia
• Acute myeloid leukemia

References

   This article is a protein-related stub. You can help WikiMD by expanding it!

   This article is a medical stub. You can help WikiMD by expanding it!