Prostaglandin EP1 receptor
Prostaglandin EP1 receptor (EP1) is a G protein-coupled receptor that in humans is encoded by the PTGER1 gene. It is one of four identified EP receptors, the others being EP2, EP3, and EP4, which bind with and are activated by prostaglandin E2 (PGE2).
Function
The EP1 receptor is one of the four receptors identified that mediate the actions of the prostaglandin PGE2. The activation of EP1 receptor by PGE2 results in an increase in intracellular calcium ion levels. It is expressed in various tissues, including the central nervous system, kidney, and gastrointestinal tract.
Clinical significance
EP1 has been implicated in various physiological and pathophysiological processes. It plays a role in the regulation of blood pressure, protection of the gastrointestinal mucosa, and inflammation. In the central nervous system, it is involved in nociception and fever response.
EP1 receptor antagonists have been investigated for their potential therapeutic applications. For instance, they may be beneficial in the treatment of hypertension, pain, and certain inflammatory diseases.
See also
References
External links
- "Prostanoid Receptors: EP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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