Oxaprotiline
Oxaprotiline (developmental code name CGP-6085), is a tricyclic antidepressant (TCA) that was developed in the late 1960s by Ciba, a Swiss multinational pharmaceutical company. It is a norepinephrine reuptake inhibitor with negligible effects on serotonin and dopamine reuptake.
Pharmacology
Oxaprotiline acts as a norepinephrine reuptake inhibitor and has negligible effects on the reuptake of serotonin and dopamine. It is also known to act as an antagonist of the histamine H1 receptor and alpha-1 adrenergic receptor, which may contribute to its side effect profile.
Clinical Use
Oxaprotiline is used in the treatment of depression. It has similar efficacy to other TCAs and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depressive disorders.
Side Effects
Common side effects of oxaprotiline include dry mouth, constipation, blurred vision, and dizziness. Less common side effects can include tachycardia, hypotension, and urinary retention. As with other TCAs, oxaprotiline can also cause cardiotoxicity in overdose.
See Also
- Tricyclic antidepressant
- Norepinephrine reuptake inhibitor
- Histamine H1 receptor
- Alpha-1 adrenergic receptor
References
<references />
Ad. Transform your life with W8MD's
GLP-1 weight loss injections special from $29.99
W8MD Medical Weight Loss, Sleep and Medspa offers physician-supervised medical weight loss programs: NYC medical weight loss Philadelphia medical weight loss
Affordable GLP-1 Weight Loss ShotsAffordable GLP-1 Weight Loss Shots
Budget GLP-1 injections NYC (insurance & self-pay options) Popular treatments:
- Semaglutide starting from $29.99/week
- Tirzepatide starting from $45.00/week
✔ Most insurances accepted for visits ✔ Prior authorization support when eligible
Start your physician weight loss NYC journey today:
📍 NYC: Brooklyn weight loss center 📍 Philadelphia: Philadelphia weight loss center
📞 Call: 718-946-5500 (NYC) | 215-676-2334 (Philadelphia)
Tags: Affordable GLP1 weight loss NYC, Wegovy NYC, Zepbound NYC, Philadelphia medical weight loss
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
.svg){kind=link}