Spastic paraplegia 10

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Alternate names

SPG10; Autosomal dominant spastic paraplegia

Definition

A rare type of hereditary spastic paraplegia that can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia and extensor plantar responses, presenting in childhood or adolescence, or as a complex phenotype associated with additional manifestations including peripheral neuropathy with upper limb amyotrophy, moderate intellectual disability and parkinsonism. Deafness and retinitis pigmentosa were reported in one case.

NIH genetic and rare disease info

Spastic paraplegia 10 is a rare disease.

Rare and genetic diseases

Rare diseases - Spastic paraplegia 10

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Spastic paraplegia 10

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